Argyris has obtained degrees from the National Technical University of Athens, Greece and Imperial College London. As a post-doctoral researcher, he has worked in Cambridge and Oxford University with Prof. Dame Carol Robinson, as well as spending time at UCSF with Prof. Andrej Sali. His recent work led to the development of a mass spectrometry-based hybrid method for assembly modelling of large and heterogeneous protein complexes. This work was published in Nature Methods and Nature Chemistry.
Current Members
I graduated from King’s College London in 2015 with a first-class honours degree in Biochemistry. I developed an interest into protein structure, function and interactions using of mass spectrometry and hence I decided to uptake a PhD in protein structural biology in a mass spectrometry focused group. I am also a Graduate Teaching Scholar (GTS) within the Department of Chemistry. Co-supervised by Prof. Maria (Sasi) Conte (King’s College London).
Andy Lau (PhD student, 4th Year)
I develop computational tools for integrating data from different structural techniques, such as native MS, IM-MS, XL-MS, HDX-MS, cryo-EM and molecular dynamics, to build accurate models of large protein complexes. Co-supervised by Prof. Franca Fraternali and Dr. Antoni Borysik (King’s College London).
I use a combination of native MS, lipidomics, crystallography, ion-mobility MS, and HDX-MS to investigate how protein-lipid interactions affect membrane protein oligomerisation, function, and conformational dynamics. I mainly focus on membrane protein transporters. Co-supervised by Dr. Bernadette Byrne and Dr. Aylin Hanyaloglu (Imperial College London).
KJ Hansen (PhD student, 3rd Year)
My project looks at the conformational dynamics of antibodies in solution and gas-phase. This is achieved by use of hydrogen-deuterium exchange and ion mobility mass spectrometry. Molecular modelling and molecular dynamics are also implemented in this project. Co-supervised by Prof. Brian Sutton (King’s College London).
My project involves investigating the molecular mechanism of membrane transporters and disease-related mutant variants, using a combination of native MS and HDX-MS. Co-supervised by Prof. Paula Booth (King’s College London).
Former Members
Dr Chloé Martens (Research Associate)
Dr Jurgen Claesen (Visiting Research Associate)
Evan Roberts (Physics MSci)
Duniya Ahmed (Chemistry MSci)