News
2018
Nov
- Argyris attends the ASMS Sanibel Conference (2019) in Florida, USA
- “Deuteros: software for rapid analysis and visualization of data from differential HDX-MS” published in Bioinformatics
- "ATP-induced asymmetric pre-protein folding as a driver of protein translocation through the Sec machinery" published in eLife
- Preprint for “Structural basis of Cullin-2 RING E3 ligase regulation by the COP9 signalosome” deposited to bioRxiv
- “A mass spectrometry-based modelling workflow for accurate prediction of IgG antibody conformations in the gas phase” published in Angewandte Chemie
- “Native mass spectrometry goes more native: investigation of membrane protein complexes directly from SMALPs” published in Chemical Communications
- Congratulations to Zainab for winning the King's College London Daniell Prize for outstanding PhD research!
Oct
- “Direct protein-lipid interactions shape the conformational landscape of secondary transporters” published in Nature Communications
- “POPPeT: a new method to predict the protection factor of backbone amide hydrogens” published in Journal of American Society of Mass Spectrometry
- Welcome to the group, Ruyu (Ruby) Jia! Ruby’s project will be investigating the relationship between membrane transporters and lipids.
Sep
- Preprint for “Deuteros: software for rapid analysis and visualization of data from differential HDX-MS” deposited to bioRxiv
- Argyris, Andy and KJ attend the 29th BMSS Annual Meeting in Cambridge, UK
- KJ attended the 2nd Autumn Workshop in Structural Proteomics in Nurmes, Finland
Jul
- “Specific cardiolipin-SecY interactions are required for proton-motive force stimulation of protein secretion” published in Proceedings of the National Academy of Sciences USA
- Congratulations to Zainab for winning the best poster at the 32nd Annual Symposium of The Protein Society held in Boston, USA!
May
- "Analysing protein architectures and protein-ligand complexes by integrative structural mass spectrometry" published in Journal of Visualized Experiments
- “Structural basis for isoform-specific kinesin-1 recognition of Y-acidic cargo adaptors” published in eLife
April
- "Structural Lipids Enable the Formation of Functional Oligomers of the Eukaryotic Purine Symporter UapA" published in Cell Chemical Biology
February
- Congratulations to KJ for passing his PhD upgrade!
January
- Congratulations to Andy for passing his PhD upgrade!
- Andy moves to Swansea for his Professional Internship for PhD students at Moleculomics. He will be developing a machine learning methods for predicting protein-protein interfaces.
2017
December
- Politis group celebrating Christmas with the Borysik group!
November
- Zainab's HerA-NurA article was published on the front cover of Nucleic Acids Research! Well done to Zainab for the brilliant paper and Andy for designing the cover image!
- “Combining chemical cross-linking and mass spectrometry of intact protein complexes to study the architecture of multi-subunit protein assemblies” published in the Journal of Visualized Experiments
- “Interrogating membrane protein conformational dynamics within native lipid compositions” published in Angewandte Chemie
October
- "Where have the Politis group been recently?" map added to Location
- "Mechanistic insight into the assembly of the HerA-NurA helices-nuclease DNA resection complex" published in Nucleic Acids Research
- Welcome Evan Roberts and Duniya Ahmed to the group! Evan (MSci Physics) will be working with Andy to develop computational modelling software with the Politis lab. Duniya (MSci Chemistry) will work alongside Chloé to develop HDX-MS methodologies for characterising membrane protein-lipid interactions
September
- Zainab gave a talk at the London Biological Mass Spectrometry Discussion Group in London, UK
- KJ and Argyris attended the 38th Annual Meeting of the BMSS in Manchester, United Kingdom
August
- Andy attended Biophysical Society's "Conformational Ensembles from Experimental Data and Computer Simulations" conference in Berlin, Germany
July
- Welcome Jurgen Claesen (Research Associate) to the group! Jurgen will be spending some time with the Politis group to develop HDX-MS modelling strategies for protein complexes
June
- Euan & Argyris attended the 65th ASMS Conference on Mass Spectrometry and Allied Topics in Indianapolis, USA
- Chloe attended the Gordon Research Conference - Mechanisms of Membrane Transport in New London, USA
May
- Zainab and Argyris attended the first International Conference on Hydrogen-Deuterium Exchange Mass Spectrometry in Gothenburg, Sweden
- Argyris, Andy And Zainab attended the first Structural Mass Spectrometry Workshop in Rehovot, Israel at the Weizmann Institute of Science
- Chloe and KJ attended the Royal Society of Chemistry's Chemical Biology Symposium in London, UK
April
- "Structural characterisation of medically relevant protein assemblies by integrating mass spectrometry with computational modelling" published in Journal of Proteomics
February
- Chloe attended the 61st Annual Meeting of the Biophysical Society held at New Orleans, USA
January
- "Surface accessibility and dynamics of macromolecular assemblies captured by covalent labelling mass spectrometry and molecular simulations" published in Analytical Chemistry
2016
November
- Congratulations to Zainab for winning an award for the best student talk, at the 2016 Swiss Group for Mass Spectrometry (SGMS) conference in Switzerland!
October
- Welcome to the group, KJ Hansen (BBSRC LIDo student)! KJ will be working with Argyris and Prof. Brian Sutton to elucidate the conformational dynamics of immunoglobulins
September
- Chloe and Zainab attended the 37th Annual Meeting of the British Mass Spectrometry Society in Eastbourne, United Kingdom
May
- "Hybrid mass spectrometry: towards characterisation of protein conformation states" published in Trends in Biochemical Sciences
April
- Zainab attended The Astbury Conversation in Leeds, UK